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Simvastatin
Zocor

  • Labistatin / Lipex / Lodales / Simovil
  • CHO004
  • In Stock

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   Manufacturer's Suggested Retail Price (MSRP) per pill is $5.14 ! Buying from us will save you at least 34.63%

Package per pill Price SAVINGS BONUS Order
10mg * 30 pills
$3.36 $100.80 $0.00
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SILVER BONUS
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10mg * 60 pills
$1.89 $113.40 $88.20
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SILVER BONUS
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10mg * 90 pills
$1.46 $131.40 $171.00
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SILVER BONUS
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10mg * 120 pills
$1.16 $139.20 $264.00
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SILVER BONUS
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10mg * 180 pills
$0.96 $172.80 $432.00
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SILVER BONUS
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   Manufacturer's Suggested Retail Price (MSRP) per pill is $6.94 ! Buying from us will save you at least 48.70%

Package per pill Price SAVINGS BONUS Order
20mg * 30 pills
$3.56 $106.80 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 60 pills
$2.09 $125.40 $88.20
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 90 pills
$1.66 $149.40 $171.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 120 pills
$1.36 $163.20 $264.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
20mg * 180 pills
$1.26 $226.80 $414.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." It reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Simvastatin is used to lower cholesterol and triglycerides (types of fat) in the blood and to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Simvastatin is used in adults and children who are at least 10 years old.

For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.

Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Metabolism: Hepatic, simvastatin is a substrate for CYP3A4. The major active metabolites of simvastatin are β-hydroxyacid metabolite and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives.

Absorption: Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues. However, because simvastatin undergoes extensive first-pass metabolism, the availability of the drug in the systemic is low. Peak plasma concentration occurs 1.3 - 2.4 hours after administration.

Route of elimination: Following an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.

Half life: 3 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Simvastatin.

Tell your doctor or pharmacist if you have any medical conditions.

Common simvastatin side effects may include: headache, constipation, nausea, stomach pain or cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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